![]() These findings demonstrate effects of OT on resting-state brain functioning in prefrontal regions subserving working memory and cognitive control, which are disrupted in PTSD. Increased resting-state alpha was associated with lower baseline plasma OT, reduced salivary OT reactivity, and more re-experiencing symptoms. The higher alpha activity was “normalized” following OT administration and under OT, group differences were no longer found. Trauma-exposed veterans showed higher resting-state alpha (8–13 Hz) activity compared to controls in the left dorsolateral prefrontal cortex (dlPFC), specifically in the superior frontal gyrus (SFG) and the middle frontal gyrus (MFG), indicating decreased neural activity in these regions. Spontaneous brain activity measured during a 2-min resting period was subjected to source-localization analysis. Plasma and salivary OT levels were assessed each session. Following OT/PBO administration, participants underwent a whole-head MEG scan. Participants participated in two experimental sessions and were administered OT or placebo (PBO) in a double-blind, placebo-control, within-subject design. ![]() In the current study the effects of OT on spontaneous brain oscillatory activity were measured in 43 veterans using magnetoencephalography (MEG): 28 veterans who were exposed to a combat-related trauma and 15 trauma-unexposed controls. Previous research demonstrated the effects of oxytocin (OT) administration on brain regions implicated in post-traumatic stress disorder (PTSD) yet OT’s effects on brain patterns in trauma-exposed veterans have not been studied. ![]() 3Department of Obstetrics and Gynecology, Hadassah, Hebrew University, Ramat-Gan, IsraelĮxposure to combat-related trauma often leads to lifetime functional impairments.2Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel.1The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel. ![]() Moranne Eidelman-Rothman 1, Abraham Goldstein 1,2, Jonathan Levy 1, Omri Weisman 2, Inna Schneiderman 1, David Mankuta 3, Orna Zagoory-Sharon 1 and Ruth Feldman 1,2* ![]()
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